수종의 탈단백 우골 이식재의 특성 비교 분석
A comparative analysis of basic characteristics of several deproteinized bovine bone substitutes
여신일, 박진우, 서조영, 이재목, 박성환, 노우창,
소속 상세정보
여신일 ( Yeo Shin-il ) - 경북대학교 치의학전문대학원 치주과학교실
박진우 ( Park Jin-Woo ) - 경북대학교 치의학전문대학원 치주과학교실
서조영 ( Suh Jo-Young ) - 경북대학교 치의학전문대학원 치주과학교실
이재목 ( Lee Jae-Mok ) - 경북대학교 치의학전문대학원 치주과학교실
박성환 ( Park Sung-Hwan ) - 경북대학교 치의학전문대학원 치주과학교실
노우창 ( Noh Woo-Chang ) - 경북대학교 치의학전문대학원 치주과학교실
KMID : 0363020090390020149
Abstract
Purpose: Deproteinized bovine bone substitutes are commonly used in dental regenerative surgery for treatment of alveolar defects. In this study, three different bovine bone minerals - OCS-B (NIBEC, Seoul, Korea), Bio-Oss (Geistlich - Pharma, Switzerland), Osteograft/N - 300 (OGN, Dentsply Friadent Ceramed. TN, USA) - were investigated to analyze the basic characteristics of commercially available bone substitutes.
Methods: Their physicochemical properties were evaluated by scanning electron microscopy, energy dispersive X-ray spectrometer (EDS), surface area analysis, and Kjeldahl protein analysis. Cell proliferation and alkaline phosphatase (ALP) activity of human osteosarcoma cells on different bovine bone minerals were evaluated.
Results: Three kinds of bone substitutes displayed different surface properties. Ca/P ratio of OCS - B shown to be lower than other two bovine bone minerals in EDS analysis. Bio-Oss had wider surface area and lower amount of residual protein than OCS - B and OGN. In addition Bio - Oss was proved to have lower cell proliferation and ALP activity due to lots of residual micro particles, compared with OCS - B and OGN.
Conclusions: Based on the results of this study, three bovine bone minerals that produced by similar methods appear to have different property and characteristics. It is suggested that detailed studies and quality management is needed in operations for dental use and its biological effects on new bone formation.
키워드
bovine bone substitute;physicochemical property;cell proliferation;alkaline phosphatase activity
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